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暱稱：小醫王

個人介紹：我是胸腔專科醫師，我病患大部份是老煙槍，不忍心他們一步一步又回到門診，什至返回加護病房，願和他們一起留下生命中的點點滴滴....

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抽菸和肺癌親密問題(16)

分類:醫定知道

小醫王(smoker) | 2008/4/22 上午 12:02:51

http://www.technologyreview.com/files/12940/dna_nicotine_x220.jpg

為什麼同樣抽菸，有些人比其他人更容易得肺癌？

同樣都抽菸，為什麼有些人菸癮不大，有些人卻菸不離手；為什麼有些人比其他人更容易得肺癌？

一家名為deCODE的冰島基因科技公司將研究報告發表在英國科學期刊《Nature》雜誌上:人類的第十五號染色體在rs1051730位置，發生了單一核?酸變異（SNP）。由於這種變異剛好發生在某些尼古丁受體分子的基因內，研究人員分析了將近一萬四千名冰島吸菸者，證實了這種變異與重度吸菸者有強烈的關聯性，而且也跟吸菸者罹患肺癌的機率大有關係。

不過，也有人不同意。法國的布瑞南博士與美國的艾默斯博士都認為，基因變異的作用，並不會使人增加菸癮，而是直接使人更容易得到肺癌。
儘管結論不太一樣，這三份研究卻一致同意，吸菸、基因與肺癌之間，確實存有某種三角關係。

(吳怡靜譯)作者：經濟學人　出處：天下雜誌 394期 2008/04

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